Donald Trump makes good on a promise but Dems cry ‘coverup’

Timing is everything, and timing explains President Trump’s decision to finally pull the ripcord and open the Obama administration’s bag of dirty tricks. With his memo giving Attorney General Bill Barr the authority to declassify any documents related to the investigation of the 2016 campaign, Trump made good on a longstanding promise. Most important, his…
Opinion | New York Post

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LeBron James’ I Promise Academy Students Scored Incredibly High Showing Major Progress

I Promise School Grand Opening Celebration With LeBron James

Source: Jason Miller / Getty

A year after its opening, the students at LeBron James’ I Promise Academy have made a complete turnaround academically.

Last year, the students scored extremely low on their state exams, putting them in the lowest percentile.  Fast forward to now and the third grade students’ test scores have jumped to the ninth percentile while the fourth graders are now in the 16th. Ninety percent of the students that met their academic goals exceeded 70 percent of students nationwide. The test scores for the I Promise Academy improved at a higher rate than 99 out of 100 schools nationally.

“These kids are doing an unbelievable job, better than we all expected,” James told The New York Times. “When we first started, people knew I was opening a school for kids. Now people are going to really understand the lack of education they had before they came to our school. People are going to finally understand what goes on behind our doors.”

The excitement comes from their test scores from the Measures of Academic Progress assessment.

When James started this school he was praised for giving back to his community and focusing on education however no one knew what to expect and some doubted the school would be deemed good. The students who fill the third and fourth grade classrooms were already labeled as some of the worst students in Akron. Thankfully,  the school and students defied the odds and have exceeded expectations so far.

 

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Immune System Therapy Shows Wider Promise Against Cancer

(Anna Carlstrand via AP)

ATLANTA (AP) — A treatment that helps the immune system fight deadly blood cancers is showing early signs of promise against some solid tumors, giving hope that this approach might be extended to more common cancers in the future.

The treatment, called CAR-T therapy, involves genetically modifying some of a patient’s own cells to help them recognize and attack cancer. Richard Carlstrand of Long Key, Florida, had it more than a year ago for mesothelioma, an aggressive cancer of the lining of the lungs.

“We were going into unknown territories” to try this, he said, but now he shows no sign of cancer and “I couldn’t be happier.”

Results on his and other cases were discussed Sunday at an American Association for Cancer Research conference in Atlanta.

The first CAR-T therapies were approved in 2017 for some leukemias and lymphomas. After being altered in the lab, the modified immune system cells are returned to the patient through an IV, which puts them right where the cancer is — in the blood.

But that approach doesn’t work well if the cells have to travel far through the bloodstream to get to tumors in the lung, breast, colon, or other places.

“Solid tumors are notorious for not letting the immune cells enter,” and not enough may make it in to have an effect, said Dr. Prasad Adusumilli of Memorial Sloan Kettering Cancer Center in New York.

A bigger worry is that the proteins on solid tumor cells that these therapies target also are found on normal cells at lower levels, so the therapy might harm them, too.

Adusumilli helped design a new CAR-T to try to avoid these problems and tested it on 19 patients with mesothelioma and two others with lung and breast cancer, respectively, that had spread to the chest lining. About 150,000 patients in the U.S. each year face this situation.

The modified cells were injected directly into the chest where the tumors were. A genetic safety switch was added so a medicine could be given to destroy the cells if they caused harm.

After the therapy, one patient was able to have surgery and radiation, and is doing well 20 months later with no further treatment. Fifteen others were well enough to start on a drug that boosts the immune system in a different way.

Eleven of the 15 have been studied long enough to report results. Two had signs of cancer disappear for about a year, although one later relapsed. Six saw their tumors shrink. Three saw their cancer worsen.

There were no severe side effects although some patients had temporarily low blood counts and fatigue.

Grants from the federal government and foundations paid for the work and a larger study is planned. Sloan Kettering has licensed the treatment to Atara Biotherapeutics and may get payments from it, as may Adusumilli.

A second study tested a different CAR-T therapy in 10 children and adults with advanced sarcomas — cancers that originate in various soft tissues or bones. Unlike other CAR-Ts that are usually given just once, this one was given multiple times, up to 15 in one patient’s case, if there were signs it was helping.

“From a single blood draw we make a large amount of the CAR-T cells and then we freeze them” and give them through an IV as needed, said Dr. Shoba Navai of Baylor College of Medicine in Houston.

Two of the 10 patients had all signs of cancer disappear, one for 17 months and the other for nearly three years, so far. Three others had their disease stabilized. Five worsened despite treatment.

Side effects were similar to the other study. The therapy seems safe “and we have early signs that this treatment approach may help,” Navai said.

Several foundations and charities paid for the work.

“These studies are showing there may be a path forward in solid tumors” with CAR-T therapies, said Dr. Louis Weiner, director of the Georgetown Lombardi Comprehensive Cancer Center and one of the conference leaders. It may hold promise for some cancers of the stomach, breast, colon, lung and other areas, he said.

Cost is a big issue — current CAR-T therapies are around $ 400,000 but can be made for far less than that in research centers. Doctors say they hope the cost will come down as more come on the market and find their way to wider use.

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Alzheimer’s treatment holds promise for primary progressive aphasia patients

Scientists have discovered that an existing therapy frequently used to treat Alzheimer’s disease might also work on patients with primary progressive aphasia (PPA), a type of dementia that destroys language and currently has no treatment.
Child Development News — ScienceDaily

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Lenders promise savings on student loans, but here’s why the reality is different than advertised

Student loan refinancing companies say they offer borrowers a way to save thousands of dollars on their debt, by allowing them to pay off their loans at a lower interest rate, in less time.
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Trump Caves to MAGA Allies on ‘Sacred’ Border Wall Promise

Jacquelyn Martin/Shutterstock

Earlier this week, Donald Trump did what he so often does in times of tense political standoff: He worked the phones with friends and allies, watched numerous hours of television punditry, and reacted viscerally to critics who said he was going limp on his hardline promises.

This week, the warnings from the MAGA faithful were about his border wall and they stressed that the president had better hold his ground and shut the government shutdown before bending again on funding for his big, beautiful wall.

On Thursday, Trump appeared to heed those grave warnings. Following an afternoon meeting at the White House, outgoing House Speaker Paul Ryan told reporters that the president “will not sign” the funding bill as is to keep the federal government open, citing conflict over wall money.

Read more at The Daily Beast.

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The President has become increasingly sensitive to criticism that he’s backing off his border wall promise, sources say

President Donald Trump has become increasingly sensitive to criticism that he’s backing off his signature promise to build a wall along the US-Mexico border, three sources familiar with his concern tell CNN, as aides fear the administration’s chances for securing funding for it have sunset.


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Health privacy advocates worry DeepMind will break its promise not to share health data with Google

DeepMind Health says that it will be absorbed into Google Health, but it still won't be sharing patient health information with its parent company. Its critics remain concerned.
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Promise fulfilled 25 years later with TV film “My Dinner with Herve”

Sacha Gervasi brings the memoirs of Herve Villechaize to life, as he promised the diminutive ‘Fantasy Island’ actor 25 years ago, with a film about his life. Rough Cut – no reporter narration.


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